IN EACH OF THESE TRIALS, CONDUCTED WITHOUT REGARD TO THE TIMING OF DOSE AND SEXUAL INTERCOURSE, CIALIS DEMONSTRATED ...

CIALIS, when taken once daily, was shown to be effective in improving erectile function in men with erectile dysfunction (ED). In the second of these studies, a total of 483 patients were evenly randomized to 1 of 6 groups: 3 different dosing groups (placebo, CIALIS 10, or 20 mg) that were instructed to attempt intercourse at 2 different times (24 and 36 hours post-dosing). At the 36-hour timepoint (more specifically, 33 to 39 hours), 49133 (37%) of patients reported at least 1 successful intercourse in the placebo group versus 88137 (64%) in the CIALIS 20-mg group.

At the 24-hour timepoint, (more specifically, 22 to 26 hours), 53144 (37%) patients reported at least 1 successful intercourse in the placebo group versus 84138 (61%) in the CIALIS 20-mg group. In this randomized, placebo-controlled, double-blinded trial, 223 patients were randomized to placebo, CIALIS 10, or 20 mg. Using a stopwatch, patients recorded the time following dosing at which a successful erection was obtained. Several studies were conducted with the objective of determining the optimal use of CIALIS in the treatment of ED. In one of these studies, the percentage of patients reporting successful erections within 30 minutes of dosing was determined.

Patients were free to choose the time interval between dose administration and the time of sexual attempts. CIALIS, when taken as needed up to once per day, was shown to be effective in improving erectile function in men with erectile dysfunction (ED). After single oral-dose administration, the maximum observed plasma concentration (Cmax) of Fildena is achieved between 30 minutes and 6 hours (median time of 2 hours).

In a study to assess the effects of a single dose of Fildena 40 mg on vision (N=59), no effects were observed on visual acuity , intraocular pressure , or pupilometry. Of note, in this study, in some subjects who received Fildena followed by sublingual nitroglycerin in the post-exercise period, clinically significant reductions in blood pressure were observed, consistent with the augmentation by Fildena of the blood-pressure-lowering effects of nitrates. In these two studies, more patients had clinically significant decreases in blood pressure on the combination of Fildena and alcohol as compared to alcohol alone.

A study was conducted to assess the interaction of sustained-release metoprolol (25 to 200 mg daily) and Fildena 10 mg. Following dosing, the mean reduction in supine systolic/diastolic blood pressure due to Fildena 10 mg in subjects taking metoprolol was 53 mm Hg, compared to placebo. A study was conducted to assess the interaction of enalapril (10 to 20 mg daily) and Fildena 10 mg. Following dosing, the mean reduction in supine systolic/diastolic blood pressure due to Fildena 10 mg in subjects taking enalapril was 41 mm Hg, compared to placebo.
https://scholarlycommons.law.hofstra.edu/cgi/viewcontent.cgi?article=1283&context=jibl

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